A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division

A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division

Blog Article

The roles of long non-coding RNAs (lncRNAs) in regulating cancer and Video Accessories stem cells are being increasingly appreciated.Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity.Here we report a novel LncRNA, Lnc34a, that is enriched in colon cancer stem cells (CCSCs) and initiates asymmetric division by directly targeting the microRNA miR-34a to cause its spatial imbalance.Lnc34a recruits Dnmt3a via PHB2 and HDAC1 to methylate and deacetylate the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent of its upstream regulator, p53.Lnc34a levels affect CCSC self-renewal and colorectal cancer (CRC) growth in xenograft models.

Lnc34a is upregulated in Candle Holder late-stage CRCs, contributing to epigenetic miR-34a silencing and CRC proliferation.The fact that lncRNA targets microRNA highlights the regulatory complexity of non-coding RNAs (ncRNAs), which occupy the bulk of the genome.